Nanni Moretti once again muses on the ebb and flow of life in April 1996, as he is about to become a father for the first time and finds himself unable to focus on his documentary about the upcoming general elections, where the left is heading into a rematch against Berlusconi.

In the 15th century, in a poor Italian village, the monks of a modest convent take up an abandoned baby. Unfortunately, for all their efforts, they prove unable to trace his parents. So they set up providing tender loving care to the little boy. Marcellino lives a happy life among the men of God but, as he grows up, he misses his mother more and more.