A high concept thriller that tells the story of Dr. Ephraim Goodweather, the head of the Center for Disease Control Canary Team in New York City. He and his team are called upon to investigate a mysterious viral outbreak with hallmarks of an ancient and evil strain of vampirism. As the strain spreads, Eph, his team, and an assembly of everyday New Yorkers, wage war for the fate of humanity itself.

Hazel suffers from a crippling case of agoraphobia - so much so that it causes a rift between her and her mother, Dee. They agree that Hazel will go to a treatment facility to help her deal with her fear, transported by a driver and specialty van from the facility. But when two masked gunmen attack them on the desert road, Hazel has to battle her fears so she and her mother can survive.