Set in the 1990s, these are the life and times of Amado Carrillo Fuentes, a man who became the head of the Juárez cartel. Nicknamed “El Señor de los Cielos” (Lord of the Skies) because of the large fleet of airplanes he used to transport drugs, he was also known for washing more than $200 million through Colombia to finance his huge fleet. He is described as the most powerful drug trafficker of his time.

A story of revenge and ambition, seduction and betrayal; all told from the perspective of an offended and abused woman named Altagracia. Altagracia represents the hundreds of thousands of Mexican women who have been victims of the violence by faceless men who are protected by impunity. But Altagracia, transformed into a strong-willed, ruthless man-eater known as La Doña, will seek out each and every one of these men to bring them to justice.

Wrongfully accused of a crime she didn't commit, 13 year old Guadalupe Santos is sentenced to 30 years in jail, while in jail she gives birth to a baby girl who is taken from her by her older sister Milagros. 15 years later she escapes jail and meets with Daniel Moncada who turns out to be the brother of the man she was accused of killing.