Two families, abolitionist Northerners the Stonemans and Southern landowners the Camerons, intertwine. When Confederate colonel Ben Cameron is captured in battle, nurse Elsie Stoneman petitions for his pardon. In Reconstruction-era South Carolina, Cameron founds the Ku Klux Klan, battling Elsie's congressman father and his African-American protégé, Silas Lynch.

Betty Yarnell lives with her drunkard father in the North Woods mountains. Betty is shunned by the villagers whenever she ventures out to pick up her father from Abner Grimp's saloon, and her only friend is a little lamb. In debt to Abner, John Yarnell signs a note turning over his daughter to Abner in return for unlimited drinks. When Abner goes to the cabin to claim Betty, revenue officer Ralph McGibbon arrives from the city and rescues her. Abner sends his Indian partner Dark Cloud, but Ralph rescues Betty again, although he is badly beaten up.

Catherine Montour, a striking half-breed Indian princess, and mistress of King George III aspires to become the first Queen of America when the revolution breaks out.

During the French and Indian War, Col. Munro’s daughters journeying to Fort William Henry are betrayed by guide Magua. Hawkeye and Mohicans rescue them, but Hurons capture Cora. Uncas dies saving her; Hawkeye avenges him, symbolizing the Mohicans’ demise.

Sierra Jim, wounded and desperate, flees from the sheriff and is given refuge in the cabin of a young girl, the sweetheart of the pony express rider.

Suspected of theft, the Indian was discharged on the ranch-hand's accusation, but the foreman's suspicions against the hand were confirmed in time to reinstate the Indian. In gratitude the Indian captured the thief with the ranchero's money and saved the girl as well.

Wild Flower follows her banished lover, Gray Fox, into the wilderness. Her departure is witnessed by Silver Fawn, who mistakenly thinks Wild Flower is stealing her fiancé. Silver Fawn sets out in pursuit and jealously attacks Wild Flower. They fall into the river but are rescued by Gray Fox.

Molly Kite, the neglected child of a drunken father, rouses the sympathy of the minister, Mr. Shipton, who also teaches the school at Dead Tree. The minister-school-master persuades some of his parishioners to give the girl decent clothes, and he coaxes her into attending school. At first unruly and sullen, she gradually comes to feel that the minister is her best friend. One day she happens to see him meet a strange girl on the street. Apparently overjoyed, he kisses the stranger. Molly rushes into the house, tears off her new clothes, and vows she will never go to school again.

A Jesuit missionary and his Native American disciple converting a tribe, facing persecution, witnessing miracles, and dealing with a witch whose daughter, Monoka, is saved from blindness and evil spirits by their faith, all while Monoka and the disciple Abasan fall in love.

As a baby, John Ermine is stolen from a wagon train by the Crow Indians and is adopted by Chief Fire Bear. John grows to manhood, ignorant that he is a white man until his parentage is disclosed to him by Crooked Bear, a white hermit who is on friendly terms with the Crows. Crooked Bear teaches John the language and customs of the white man's civilization, impressing upon him that it is his sacred responsibility to keep peace between the white men and the Indians.

Gray Cloud (Dark Cloud) successfully woos Dove Eyes (Mary Pickford). But after he brings his bride home to his tent, he is shadowed by a jealous rival (Dell Henderson) who leaves him for dead when he falls into a pit during a hunting trip. Despairing over Gray Cloud's inexplicable absence, Dove Eyes becomes so ill that the envious rival relents, rescues the trapped warrior, and makes possible the couple's reunion. Based on the story 'Legend of We-No-Nah' by Mrs. James H. Ryan.

A lovely castaway is believed to be a goddess by the local natives. Popular dancer Mlle. Doraldina wrote the story to this film especially to highlight her talents, which trade paper Moving Picture World called "frankly sensual and of the athletic order."

John Stafford is unjustly arrested on the eve of his marriage for the murder of an old gentleman whose body was found in his guardian's library. The young man is taken to the penitentiary, but eludes his guards and escapes. His sweetheart engages a noted detective who finds a small Hindu image in the hand of the dead man.