The story of the early days of Deadwood, South Dakota; woven around actual historic events with most of the main characters based on real people. Deadwood starts as a gold mining camp and gradually turns from a lawless wild-west community into an organized wild-west civilized town. The story focuses on the real-life characters Seth Bullock and Al Swearengen.

A group of young gunmen, led by Billy the Kid, become deputies to avenge the murder of the rancher who became their benefactor. But when Billy takes their authority too far, they become the hunted.

A mysterious preacher protects a humble prospector village from a greedy mining company trying to encroach on their land.

Harvard graduate James Averill serves as the sheriff of prosperous Jackson County, Wyoming, standing at the center of a conflict between impoverished immigrants and affluent cattle farmers. Politically connected ranchers enlist mercenary Nathan Champion—who is also vying for the affections of local madam Ella Watson—to combat the immigrant uprising. As tensions escalate, both Averill and Champion start to question their decisions.

Trucker Rubber Duck and his buddies Pig Pen, Widow Woman and Spider Mike use their CB radios to warn one another of the presence of cops. But conniving Sheriff Wallace is hip to the truckers' tactics, and begins tricking the drivers through his own CB broadcasts. Facing constant harassment from the law, Rubber Duck and his pals use their radios to coordinate a vast convoy and rule the road.

Rabbi Avram arrives in Philadelphia from Poland en route to San Francisco where he will be a congregation's new rabbi. An innocent and inexperienced traveller, he is tricked by con men to pay for the trip to go west, then they leave him and his belongings scattered along a deserted road. He is befriended by a stranger, Tommy, who is a bank robber and have many adventures during their journey.

Ayame, a courtesan, attracts the attention of street vendor Kisuke and decides to run away with him to America. Unfortunately, a crazed tattoo artist is obsessed with Ayame's perfect skin as a potential canvas, so he kills Kisuke to keep Ayame in Japan. Later, Ayame is sold to a brothel in Yokohama. Kisuke's ghost possesses her, causing his image to appear tattoo-like on her skin whenever she has sex.

Two gamblers must leave New York City after one loses a lot of money. Doing what all gamblers in trouble would do, they hurry to the gambling capital Las Vegas to turn their luck around.