Van Wilder has been attending college for far too many years and is scared to graduate, but Van’s father eventually realizes what is going on. When he stops paying his son's tuition fees, Van must come up with the money if he wants to stay in college, so he and his friends come up with a great fund-raising idea – throwing parties. However, when the college magazine finds out and reporter Gwen is sent to do a story on Van Wilder, things get a little complicated.

A team of environmentalists investigating "unchartered territory" find that someone, or rather, something has already made the land its home and proceeds to take the team out, one by one. Meanwhile, a young couple hoping for reconciliation with a long lost brother eventually find themselves in the path of the monster.