Giulio is a widower, struggling to raise three sons, Marco, Rudi, and Mimmo, as best he can. He lives in Rome's working-class Garbatella neighborhood and runs a wine shop with his two brothers. Lucia, meanwhile, comes from Milan's middle-class background; she's divorced and trying to rebuild her life with her two daughters, Eva and Alice. The two meet by chance and recognize each other: they had a fling as teenagers, many years earlier. Yet first love is never forgotten, and so Giulio and Lucia find themselves together again. Their meeting, however, changes not only the lives of a man and a woman, but also those of two families as different as could be. Two families who find themselves living under the same roof without even having had the time to get to know each other well.

Ten pair of friends will compete in a race along a path of ten thousand miles, in stages that require three days for each trip which have specific goals.

Nemo Bandera (Amendola) is one of the most influential businessmen in Puglia. His assets originate from illicit trafficking whose proceeds were invested in Deep Sea, the profitable company inherited from his father-in-law and used as a cover. One day, all of Nemo’s certainties collapse: he discovers that he is suffering from Alzheimer’s. Shocked by the news, he decides to hide it while choosing who will inherit his empire.

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