Kokuchou Academy used to be an elite school but it is now a nest of evil. Accordingly, spunky schoolgirls Miho, Yumi, Ruri and Kei form the Sailor Suit Rebel Alliance to eliminate wrongdoers from the school premises, wearing heavy makeup in order to keep their identities hidden.

In modern day Tokyo, three university students, Negishi Miyako (Neko-chan), Saiki Haruka, and Yamagishi Keiichiro, have magical powers that make them feel like outcasts. They come together one night and are transported to another world. They open a massive door and Neko finds that she is the Princess Neryulla, who must defeat the evil Duran III to free her people.

Iori, taken from an orphanage by a family for domestic work, runs away and is adopted and raised by two young men. Ten years later, she crosses paths with her former step-sister, who is soon poisoned to death, Iori being the prime suspect.