In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

Boston lawyer Mary Ross inherits a house in Plymouth, Mass., from her great-aunt and plans to sell it. But soon has a change of heart, which is complicated by local historian, Everett Mather who's research indicates that the houses location might be the site of the original Thanksgiving.

When a single dad rents the GUEST HOUSE of a wealthy bachelor, he soon discovers his new landlord's generosity does not come without a price.