In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Modern-day Texas Ranger, Cordell Walker's independent crime-solving methods have their roots in the rugged traditions of the Old West. Walker's closest friend is former Ranger, C.D. Parker, who retired after a knee injury, and now owns "C.D.'s," a Country/Western saloon/restaurant. Rookie Ranger, James "Jimmy" Trivette is an ex-football player who bases his crime-solving methods on reason and uses computers and cellular phones. Alex Cahill is the Assistant DA who shares a mutual attraction with Walker, but often disagrees with his unorthodox approach to law enforcement.

A heroic group of teens sheltered from the dangers of the post-apocalyptic world receive a message that inspires them to leave the safety of the only home they have ever known and embark on a cross-country journey to find the one man who can possibly save the world.

Bored socialite Florence Pancho Barnes decides to learn to fly.

Bonnie Parker is estranged from her husband while still only just barely eighteen. Clyde Barrow, a handsome charmer who is in love with Bonnie, is a small-time thief, 'borrowing' cars to teach Bonnie to drive. He falls in with W.D. Jones, and their crime levels quickly rise. Soon Bonnie is dragged in with them, due to her love for Clyde, and within a short space of time, everyone is baying for the blood of Bonnie and Clyde.

An aging playboy throws a party to celebrate the first weekend in his new Hamptons home, but his young party guests begin suffering a series of bizarre accidents.

Two car thieves steal an FBI surveillance van and become invested in the marriage unraveling inside a bugged suburban home.

A brutal double murder in a hotel room. A suspect confesses at the scene. An open and shut case turns into a psychological thrill ride as tough NY detective, Gloria Hernandez starts a crusade to prove confessor Janie Holtz innocent despite her adamant admissions of guilt.