Cate Walford's relationship with vicious, business tycoon husband, Phillip, is on the ropes and their tempestuous home life is trapped in a tangled web of lies and manipulation. Through a shocking twist of fate, this dark and murky world collides with the seemingly disparate and disconnected, warm and loving world of a widow and her footy star son and musical daughter.

Karla, a young medical student, is trying to cure her brother, Blake, from a terminal sleep illness called Fatal Familial Insomnia, where you are unable to sleep until you die. On her quest to treat him, a more sinister reason for his condition is revealed.