Doctor Carter losts his wife and devotes his life to resurrecting her. However, every test of his C-900 formula creates hungry, flesh-eating zombies. Then, his daughter Cara contracts the virus and she and her sister strive to obtain the anti-serum.

The year is 1869, and Hell has scratched its way into post-Civil War Virginia. Murders become common, talk and fear crush the region. With hope and morality slipping from the inhabitants of Hatchet County, they call on a rogue legion of heroes to drive the evil back to where it came.

Before her mother sells their family home after the holidays, 30-something struggling author Bria reunites with her three best friends to reminisce and re-create the glory days of their high school years.