Shion and Rui are the dream team when it comes to hitting on women. Tonight was going to be another night of hooking up with girls for Shion, but he ended up taking a strange drug. When he woke up... he'd turned into a girl?! Rui came looking for Shion, but didn't recognize him, and started hitting on him...

Haruka Shinozaki has been interested in the class representative, Akiho Kousaka, since his first year in high school. She is attractive, good at sports, and is an all-around model student. Since they are in the same class this year, Shinozaki decides to confess his feelings—and, to his shock, Kousaka agrees to be his girlfriend! However, he finds that Kousaka is a bit stranger than he first thought: this seemingly perfect girl has never been in a relationship. But even though she is inexperienced, she vows to please Shinozaki in every way she can... such as learning multiple sex positions or his fetishes. Shinozaki tries to assure her that her studies into such subjects aren't necessary, but Kousaka devotes herself to making him happy in more ways than one.

Kashou Minaduki is an aspiring chef who moves away from home to open his own confection shop. While he is unpacking in his new shop, he discovers that two of his family's Nekos, Chocola and Vanilla, came along with him by hiding in cardboard boxes. After the two Nekos convince Kashou to let them stay and live with him, the three of them work together to run his shop, La Soleil. During the story, Kashou receives a couple of visits from his younger sister Shigure and the other four Nekos owned by their family.