Patrick Jane, a former celebrity psychic medium, uses his razor sharp skills of observation and expertise at "reading" people to solve serious crimes with the California Bureau of Investigation.

The show follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.

Cassie, a typical high school girl, is ditched by her childhood friends. Now she has to fight to get them back.