An anthology horror drama series centering on different characters and locations, including a house with a murderous past, an asylum, a witch coven, a freak show, a hotel, a farmhouse in Roanoke, a cult, the apocalypse and a summer camp.

The new medical director breaks the rules to heal the system at America's oldest public hospital. Max Goodwin sets out to tear up the bureaucracy and provide exceptional care, but the doctors and staff are not so sure he can succeed. They've heard this before. Not taking "no" for an answer, Dr. Goodwin's instinctive response to problems large and small is four simple words: "How can I help?" He has to disrupt the status quo and prove he'll stop at nothing to breathe new life into this underfunded and underappreciated hospital, returning it to the glory that put it on the map.

Follow Charlie Cale, a woman with an extraordinary ability to tell when someone is lying, as she hits the road and, at every stop, encounters a new cast of characters and crimes she can't help but solve.

In New York City during a drug party in the late 1960s, a wannabe Warhol starlet named "Ann" becomes a legend when her murder is caught on home movie. Chelsea, August of 1969,a slumming Southern Belle and her two visiting sorority friends are throwing a party in the hope that Andy Warhol will make an appearance.