After the death of his wife, world-class neurosurgeon Dr. Andrew Brown leaves Manhattan and moves his family to the small town of Everwood, Colorado. There he becomes a small-town doctor and learns parenting on the fly as he raises his talented but resentful 15-year-old son Ephram and his 9-year-old daughter Delia.

Monica, an angel, is tasked with bringing guidance and messages from God to various people who are at a crossroads in their lives.

Just when he's beginning to take his perfect life and marriage for granted, John discovers that he's the result of a failed government experiment to spawn a race of perfect assassins. But the closer he gets to finding out what went wrong, the weirder the truth becomes.

When Boyd dies and finds himself in the great beyond, he learns that his estranged son is about to make the worst decision of his life--and only Boyd can stop him.

A troubled psychiatrist goes in search of five schizophrenics who have escaped from a local mental institution. Infiltrating their makeshift mountain outpost, the doctor comes face to face with his own fears, limitations, and forsaken hopes as he becomes acquainted with the patients and their humorously poignant struggles.

To save the life of her dying son, Liz must venture to the desolate surface and face the monsters that drove mankind below.