Mandharam begins with the all too familiar trope - the schoolboy who spends his days dreaming about his childhood sweetheart and classmate, who, at the end of school, lets him know that she has a 'muracherukkan'.

Akbar, a powerful name in the Mangalore underworld shares his business lead with Mani Menon and Uncle Sam. They share a good relationship until Anto, grandson of Uncle Sam, creates havoc.

A pleasant road trip takes a nightmarish turn for gemologist Sunny George when he meets with an accident. As his life hangs in the balance on the edge of a cliff in the middle of nowhere, Sunny must not only contend with the great adversity he is in, but the adversaries lurking in the shadows as well.