Lucille Ball's third network sitcom, following I Love Lucy (1951–57) and The Lucy Show (1962–68).

Coogan, an Arizona deputy sheriff goes to New York to pick up a prisoner. While escorting the prisoner to the airport, he escapes and Coogan heads into the city to recapture him.

Mabel Longhetti, desperate and lonely, is married to a Los Angeles municipal construction worker, Nick. Increasingly unstable, especially in the company of others, she craves happiness, but her extremely volatile behavior convinces Nick that she poses a danger to their family and decides to commit her to an institution for six months. Alone with a trio of kids to raise on his own, he awaits her return, which holds more than a few surprises.

Ghost is an ideological musician and leader of a jazz band who would rather play his blues in the park to the birds than compromise himself. His peripatetic performances lead him to cross paths with a singer, while his masculinity is thrown into question following a violent brawl.

Brendan Byers III, one of the richest men in America, has been pronounced 4-F and can't serve his country in its war against Hitler. Byers does not take "No" for an answer and recruits other 4-F's to fight against Hitler.