Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

Smiling Friends Inc. is a small company whose main purpose is to bring happiness and make people smile. The series follows the day-to-day lives and misadventures of its representatives, the lazy, cynical Charlie, and the cheerful, optimistic Pim, as they try to cheer up and comfort the troubled people who call their company's hotline. They receive seemingly simple requests but the jobs turn out to be more complicated than they seem, making it difficult to bring happiness to the world.

After ratting out his Mafia cohorts, Giovanni Manzoni and his family enter the Witness Protection Program and relocate to a sleepy town in France. Despite the best efforts of their handler to keep them in line, Giovanni (now called Fred Blake), his wife and children can't help but resort to doing things the "family" way. However, their dependence on such old habits places everyone in danger from vengeful mobsters.

Michael, a struggling actor, dies right after a bad breakup. He finds himself awakening in a very bright room with a very strange lady and learns that he is in singles Purgatory, where he must find his soul mate in order to cross over to the other side. With limited time to find true love among other recently deceased single New Yorkers, Michael must navigate the new customs of a ghostly dating life... as if dating in life wasn't hard enough already.

The evil Dr. Hetero creates a straight ray in order to turn the world's gay population into heterosexuals, and it's up to Supertwink to stop him.

The life of Dino Condito is about to take a surprising turn. After letting down his softball team by striking out in the bottom of the ninth, his crew brands him the chooch (dummy).