Steve McGarrett returns home to Oahu, in order to find his father's killer. The governor offers him the chance to run his own task force (Five-0). Steve's team is joined by Chin Ho Kelly, Danny "Danno" Williams, and Kono Kalakaua.

Thomas Magnum, a decorated former Navy SEAL, returns home from Afghanistan and applies his military skills to become a private investigator in Hawaii taking jobs no one else will—with the help of fellow vets T.C. Calvin and Rick Wright, and former MI:6 agent, Juliet Higgins.

Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.

Four friends head to Hawaii to investigate reports of a haunting at an abandoned resort in hopes of finding the infamous Half-Faced Girl. When they arrive, they soon learn you should be careful what you wish for.

Piciu and Bila seize an unexpected opportunity from a Romanian client and move to Los Angeles. But they soon realize that they have unwittingly fallen into the world of the credit card rip-off mafia.