This movie chronicles the life and times of R. Crumb. Robert Crumb is the cartoonist/artist who drew Keep On Truckin', Fritz the Cat, and played a major pioneering role in the genesis of underground comix. Through interviews with his mother, two brothers, wife, ex-wife and ex-girlfriends, as well as selections from his vast quantity of graphic art, we are treated to a darkly comic ride through one man's subconscious mind.

A hard rock band travels to the tiny and remote town of Grand Guignol to perform. Peopled by hicks, rubes, werewolves, murderous dwarves, sex perverts, and Hitler, the town is a strange place but that doesn't stop the band's lead singer from falling in love with a local girl named Cassie. After Nazi sex perverts kill the band to satisfy their lusts, Cassie calls the rockers back from the grave to save her, the town, and maybe the world.