Thirty years ago, aliens arrive on Earth. Not to conquer or give aid, but to find refuge from their dying planet. Separated from humans in a South African area called District 9, the aliens are managed by Multi-National United, which is unconcerned with the aliens' welfare but will do anything to master their advanced technology. When a company field agent contracts a mysterious virus that begins to alter his DNA, there is only one place he can hide: District 9.

Frank, a retired hitman, has chosen to disappear and start his life anew as a private taxi driver. He befriends Lucy a young woman working at a shady downtown casino. After losing custody of her child Angela, Lucy is back on a downward spiral of drugs and high-class prostitution. One night she witnesses the murder of one of her clients, a prominent Millionaire in the city. Lucy manages to escape but the killer is out for her blood. She has no one to turn to except Frank her only friend. Frank has only killed for money but now he must kill to protect the only person who never had anybody to stand up for her.

Middle-aged businessman Jacob Zulu has become accustomed to his routine, a life which includes his wife Michelle, his daughter Natasha, his work and his fun. As a powerful CEO, with a big house, a successful spouse, a family and expensive recreational habits, Jacob feels like life will always be this easy.