The show revolves around the lives of 8-year-old Arthur Read, an anthropomorphic aardvark, his friends and family, and their daily interactions with each other.

Pack your bags, buckle your seatbelts, and get ready for an ARTHUR road trip to the family farm! Arthur's Great-Grand Uncle Theo is celebrating his 85th birthday, so the Reads (and Buster) are off to Ohio to join in the festivities. While D.W. and Arthur learn that farm life is a little different than life in Elwood City, Buster worries he may be getting in the way at this family reunion. With the help of Cousin Miles, some llamas, and a little bit of music, they all discover what it truly means to be family.

Original castmembers from the 60's series reunite as Patty fights to stop her longtime nemesis Sue Ellen from turning Brooklyn Heights High into a shopping mall.

When the prospect of an Elwood City concert by the Backstreet Boys drives everyone else into a frenzy, a disgusted Francine decides to counter with an "anti-cute" band of her own called U Stink. But things don't go quite the way she had planned.

Time to put on your party hats and dancing shoes - D.W. is turning five! When her birthday doesn't go as planned, D.W. runs away to the magical island of Ukubonga. Meanwhile, Arthur has skipped her birthday party to go on a school trip to the planetarium - but instead of transporting him into outer space, it transports him 4 years into the future! This is one party you don't want to miss.