The show revolves around the lives of 8-year-old Arthur Read, an anthropomorphic aardvark, his friends and family, and their daily interactions with each other.

When the prospect of an Elwood City concert by the Backstreet Boys drives everyone else into a frenzy, a disgusted Francine decides to counter with an "anti-cute" band of her own called U Stink. But things don't go quite the way she had planned.

A CIA agent infiltrates the research team of a scientist who seeks to capture the essence of a dying leukemia patient.

Time to put on your party hats and dancing shoes - D.W. is turning five! When her birthday doesn't go as planned, D.W. runs away to the magical island of Ukubonga. Meanwhile, Arthur has skipped her birthday party to go on a school trip to the planetarium - but instead of transporting him into outer space, it transports him 4 years into the future! This is one party you don't want to miss.

In this clay stop-motion animation, a little boy lives in a lonely, blurry world. His nearsightedness causes humiliations in the schoolyard and in his Grade 1 class. A visit to the eye doctor brings things into focus, and his first pair of glasses changes everything!