Lucia and Maria are two best friends, who have known each other from the beginning of their life, but have very different tastes and behaviors. Lucia is done with men, Maria, on the contrary, cannot be without one. One night, the perfect man shows up in Maria's bed: handsome, sensible, mature and passionate.The next morning brings up misunderstandings and lies which make the two friends split up and take a break for themselves. Maybe that young man met by chance is really the one every woman is looking for, because with his simple theories he manages to paint the perfect picture of the two women's lives.

Eli has four children, an unemployed husband and a job with an almost impossible commute. Vale is single and makes ends meet by working in clubs as a dancer. Tied by a profound emotional bond of true sisterhood, the two women's lives are two sides of the same coin, but their mutual solidarity isn’t always enough to lighten the load of their difficult circumstances.

Orlando and Lyse's is a fairy tale, a modern tale of an old man and a little girl who, unwittingly, find themselves facing the present together and the choices it brings, despite their being as distant as the rural life of a small inland village and the metropolitan life of a large European city can be.