A preacher sets out on a mission to make the almighty himself confess his sin of abandoning the world. With his best friend Cassidy, an alcoholic Irish vampire, his love Tulip, a red blooded gun towing Texan, and the power of genesis, an unholy child born from an angel and a devil, Jesse gives up everything to set the world straight with its creator.

Anxious manager Mimi, horny-for-holidays Alice, and lazy dud Shay navigate working at a deeply average suburban party store where the customer is usually right, but only because this shop and its staff are a mess.

On his way to prison, a man gets intercepted by a secretive government agency who task him to monitor a secret experiment in exchange for commuting his sentence.

Sometime in the near future, paraplegic prison inmate Matt Mills meets "The Board" of Satoshi-Telefair Industries, who thank him for joining the Program. Under pressure and with a promise to make him walk again, Mills agrees to volunteer. He is injected with a synthetic nanomaterial and suffocated, only to wake up with restored use of his legs, yet alone in a steel cell in the first spoke of an experimental apparatus - The Wheel. A series of assailants inflict a multitude of damage to Mills' body and torment his mind, yet the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.

Follows Jean Blake as she takes on the mantle of her husband, police surgeon Lucien Blake, as a solver of mysteries following his disappearance 18 months after their marriage.

Hal Donnelly, a hopeless 20-something slacker, gets his life back on track with the help of a teenage girl claiming to be his daughter from the future