During the mid-22nd century, a century before Captain Kirk's five-year mission, Jonathan Archer captains the United Earth ship Enterprise during the early years of Starfleet, leading up to the Earth-Romulan War and the formation of the Federation.

The lives of three women have a commonality: adoption. Karen is a physical therapist who regrets that, as a teenager, she gave up her daughter for adoption. Elizabeth was an adopted child and is now a successful lawyer, but her personal life lacks warmth. Lucy and her husband have failed to conceive and now hope to adopt a baby to make their family complete.