Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

John Reese, former CIA paramilitary operative, is presumed dead and teams up with reclusive billionaire Finch to prevent violent crimes in New York City by initiating their own type of justice. With the special training that Reese has had in Covert Operations and Finch's genius software inventing mind, the two are a perfect match for the job that they have to complete. With the help of surveillance equipment, they work "outside the law" and get the right criminal behind bars. 

A young programmer, Elliot, suffers from a debilitating anti-social disorder and decides that he can only connect to people by hacking them. He wields his skills as a weapon to protect the people that he cares about. Elliot finds himself in the intersection between a cybersecurity firm he works for and the underworld organizations that are recruiting him to bring down corporate America.

After a former elite agent rescues a 12-year-old Chinese girl who's been abducted, they find themselves in the middle of a standoff between Triads, the Russian Mafia and high-level corrupt New York City politicians and police.

Ever since her father drilled into her head that monogamy isn't realistic, magazine writer Amy has made promiscuity her credo. As much as she enjoys an uninhibited life free of commitment, Amy is really in a rut. While writing a profile about charming and successful sports doctor Aaron Conners, she finds herself actually falling in love for the first time -- and what's more, Aaron seems to really like her too. Amy starts to wonder if it's time to clean up her act and face her fears.

New York City is full of lonely hearts seeking the right match, and what Alice, Robin, Lucy, Meg, Tom and David all have in common is the need to learn how to be single in a world filled with ever-evolving definitions of love.

In Manhattan, a bike messenger picks up an envelope that attracts the interest of a dirty cop, who pursues the cyclist throughout the city.

After two tours of duty, Joe's life unravels as he waits for PTSD treatment.

On the hottest day of the year, an unknown virus spreads throughout inner-city Philadelphia. The infected victims, crazed by dehydration, begin attacking other residents of the neighborhood in gruesome ways. When the military is brought in to contain the situation, but realize they can't come up with a vaccine quickly enough, they fence off the area and let everyone die. A group of locals, stuck in the basement of their building, behind the fences, and separated from their family members, band together to try to survive.