After killing Alison Sumner and being seemingly killed by Robert Kersey, James Kirby is being transferred to the local morgue. But he isn't dead and kills the coroner and his assistant before escaping into the night. Now anyone who encounters this unstoppable creature is in danger of losing their lives. Who can finally stop this madness, once and for all.

The first vampire himself Vlad Tepes arrives in the sleepy community of Willcox and quickly turns an innocent private nurse into his vampire queen. He then has her commit acts of murder on the communities less desirable and draining them of their blood, while also supplying him with a female representing all 8 blood types to become his brides. Damien Cruz investigates the murders and disappearances, which at first he believes Nicole or the mysterious priest Father Nero could be responsible for. But what will happen when Vlad realizes how close Damien is getting to discovering his evil deeds.

A man with horrible psychological problems snaps and goes on a short murder spree before being gunned down by the local Sheriff and his deputy. What should be the end of the story is only the beginning as an ambitious doctor decides to test his latest experimental drug on the body of the man. In a Frankenstein-like twist, the drug works all-too-well, and the man comes back, now with super human strength and is near indestructible.