In Tree Hill, North Carolina two half brothers share a last name and nothing else. Brooding, blue-collar Lucas is a talented street-side basketball player, but his skills are appreciated only by his friends at the river court. Popular, affluent Nathan basks in the hero-worship of the town, as the star of his high school team. And both boys are the son of former college ball player Dan Scott whose long ago choice to abandon Lucas and his mother Karen, will haunt him long into his life with wife Deb and their son Nathan.

The New York office of the FBI brings to bear all their talents, intellect and technical expertise on major cases in order to keep their city and the country safe.

The new medical director breaks the rules to heal the system at America's oldest public hospital. Max Goodwin sets out to tear up the bureaucracy and provide exceptional care, but the doctors and staff are not so sure he can succeed. They've heard this before. Not taking "no" for an answer, Dr. Goodwin's instinctive response to problems large and small is four simple words: "How can I help?" He has to disrupt the status quo and prove he'll stop at nothing to breathe new life into this underfunded and underappreciated hospital, returning it to the glory that put it on the map.

Skeptical forensic psychologist Kristen Bouchard joins priest-in-training David Acosta and technology expert Ben Shakir as they investigate supposed miracles, demonic possessions, and other extraordinary occurrences to assess for a scientific explanation or if something truly supernatural is at work.

Elliot and Beverly Mantle are twins who share everything: drugs, lovers, and an unapologetic desire to do whatever it takes — including pushing the boundaries on medical ethics — in an effort to challenge antiquated practices and bring women’s healthcare to the forefront.

Suspicious that her colleague is responsible for a series of mysterious patient deaths, a nurse risks her own life to uncover the truth.

Struggling but unapologetically living on her own terms, Inez is moving from shelter to shelter in mid-1990s New York City. With her 6-year-old son Terry in foster care and unable to leave him again, she kidnaps him so they can build their life together. As the years go by, their family grows and Terry becomes a smart yet quiet teenager, but the secret that has defined their lives threatens to destroy the home they have so improbably built.

In the wake of a tragedy, a grieving widower turns to a mysterious self help book from the dark web written by an eccentric guru, which promises to unlock the power to fly.

A recovering kleptomaniac plots an impromptu Christmas dinner with her unconventional family to win back her ex-boyfriend, but an unexpected proposal reveals old habits die hard.