Don Matteo is a thoroughly ordinary Catholic priest with an extraordinary ability to read people and solve crimes. He’s a parish priest who never met an unjustly accused person he didn’t want to help.

Newlyweds Dario and Luciana discover that their quiet neighbors are hired assassins who killed a politician – and become their next target.

A brave scientist has been studying thousands of cases related to alien abductions. By placing abductees under hypnosis, he arrives at the unsettling discovery that for thousands of years, a variety of extra-terrestrial races have been installing their active memories in abducted people's brains. These alien races exploit a powerful source of energy that only humans have: the Soul.

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Sergio has a degree in botanics, but cannot find a job. Then, he gets the announcement that his former girlfriend is getting married.

Sara, a quite librarian reluctant to enter into an affair following one that went wrong, and Bruno, a seemingly cynical guy looking for a one-night stand, become attracted to each other.