Moggina Manasu focuses on the confused state of mind of teenage girls and their relationships with boys. It also touches on teenage pregnancy and ragging in colleges, camaraderie with seniors, and teenagers' disrespect towards their parents and studies.

Santhu is the typical do-gooder youngster, who is also the angry young hero. He falls for college student Ananya after a series of chance meetings. But, there's also dreaded don Deva in the picture forming the triangle.