Although strangers Sara and Jonathan are both already in relationships, they realize they have genuine chemistry after a chance encounter – but part company soon after. Years later, they each yearn to reunite, despite being destined for the altar. But to give true love a chance, they have to find one another again.

Unceremoniously dumped by his college girlfriend Margaret during a trip to Cambodia, lovelorn American Keith returns to Philadelphia and teams with his best friend Chainsaw to form a "relationship investigation" team devoted to revealing unfaithful husbands, wives, boyfriends, and girlfriends for the two-timing louses that they truly are.

The story of fashion designer Madame de Void's love for her pup, Blot, as she grooms him for fur.