An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.

After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.

T.H.E.Y. has programmed Sandra West to become a T.H.E.Y. assassin. Can Superseven stop her from killing more agents and prevent her head from exploding like a poodle in a microwave?