A team of environmentalists investigating "unchartered territory" find that someone, or rather, something has already made the land its home and proceeds to take the team out, one by one. Meanwhile, a young couple hoping for reconciliation with a long lost brother eventually find themselves in the path of the monster.

In this sequel, Bloodsucka Jones and his friends must battle zombies, weight gain, and tumbleweeds as they attempt to save the world from certain doom.