Madhuri Talkies is a Bhojpuri neo-noir set in the heartlands of Varanasi and Mughalsarai, where crimes against women and political tyranny rule the roost. One man sets forth on a deeply personal mission to avenge the love of his life and goes on a bloody rampage that puts the most powerful people of the city, from scheming politicians to police officers and the media, on high alert.

Hamid (Yashpal Sharma) is a righteous man, who despises anyone who poses a threat to his Bakarwal community (a nomadic tribe residing in upper Kashmir, mainly working as goatherds and shepherds) and the country in general. But all hell breaks loose when one of his own succumbs to pressure from a bunch of terrorists.