Palermo, Sicily, 1980. Mafia member Tommaso Buscetta decides to move to Brazil with his family fleeing the constant war between the different clans of the criminal organization. But when, after living several misfortunes, he is forced to return to Italy, he makes a bold decision that will change his life and the destiny of Cosa Nostra forever.

Marco, a teacher from Milan, relocates to Palermo and takes a temporary job teaching in a juvenile detention centre while he waits for a high school teaching position. He tries to understand and motivate his handful of students, encouraging them to stand up for their rights, finding out about their histories: Natale, in for murder and enamored with the Mafia; Pietro, who can't seem to stay out of jail; Claudio, barely 14 and learning to stand up for himself; and Mery, a trans sex worker, who was arrested after a fight with a trick who didn't want to pay her, and is now stuck in a male prison.

TUFO tells the story of the Cutrò family and their resistence agianst the mafia as witnesses of justice.

Young men with no future have little in the present as well. Natale is released from prison: he takes up with his friends again but none can find work. Claudio, from Palermo, gets out of juvenile detention in Naples and he's met by Vita, a girl who's come from home to run away with him. Where can they go? A young dad, whose potato stall at the market is shut down because he has no permit, takes his two small children to the beach and yells at them. Mario, gay, a prostitute in drag, gets a visit from his mom; he offers tea, then finds the water to his apartment is shut off. Social workers drop by, parole officers file reports. What hope is there? What options besides crime?