Lifelong friends Maddie, Helen and Dana Sue lift each other up as they juggle relationships, family and careers in the small Southern town of Serenity.

After North Jackson High's long-time principal steps down to tend to his ailing wife, Neal Gamby and Lee Russell, the school's vice principals, are forced to put their mutual disdain aside and form an unholy alliance in order to sabotage the newly appointed principal, Dr. Belinda Brown.

Earl Stone, a man in his eighties, is broke, alone, and facing foreclosure of his business when he is offered a job that simply requires him to drive. Easy enough, but, unbeknownst to Earl, he's just signed on as a drug courier for a Mexican cartel. He does so well that his cargo increases exponentially, and Earl hit the radar of hard-charging DEA agent Colin Bates.

An unassuming high schooler finds himself inexplicably drawn to the free-spirited new girl, whose unconventional ways change how they see themselves…and their world.

Erwin, a girl genius, is the youngest student in high school. Unfortunately she struggles with social isolation. When she meets fellow science guru, Winston, they team up to invent a chemical that changes the high school hierarchy forever.

The restaurant is dead in more ways than one. A huge party has canceled and dashed their hopes of a big holiday tip. Surviving the shift becomes much more than side work and a deep clean when a Karen, unhappy with her service, goes on a spree to murder the entire staff.

After being wrongfully arrested for murder, Monica has finally been proven innocent. All charges have been dropped and the police have shifted their focus to Simone, who has seeming disappeared. But Simone is bonding with her daughter Joy.

Carmilla inadvertently infects Ron, Fang, and Corey with her vampirism. Unaware of their condition, these three misfit vampires' hysterical misadventures illuminate the sudden changes in their nature. While attending a support group recommended by Dr. Acula for what is thought to be a medical condition, the three connect back with Carmilla and learn the truth of their new existence. Cast out by Martin and the old vampires, pursued by the determined Eddie Van Helsing, Ron and Carmilla seek to maintain some humanity and lead their menage through the challenges of vampire life in the modern world.