Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.

Bob is coming to terms with his unsuccessful attempts at becoming an actor when he is bitten by a vampire named Susan - the daughter of a crazed vigilante slayer.

Guy is a television editor with problems. His boyfriend Tommy has just broken up with him and moved out. He's under pressure to deliver his latest episode, but the climactic scene just isn't working. And time is running out.

An Army officer arrives at a woman's home to announce that the Army's new algorithms predict that her son-who just enlisted yesterday-will die in battle. Naturally, she's upset, but when she learns that her son will become a hero in the process, she quickly adjusts to the situation.