In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

Bradin, Nikki and Derrick are three kids from an average normal Kansas household. Their whole life is thrown upside-down when their parents are tragically killed in a car accident. Ava Gregory, their aunt, gets custody of her niece and nephews, and they move into her Californian home, in Summerland.

Devi lives alone in a bunker with one precious window to the war-ravaged world outside. One day, Devi hears a sound outside her window, and she sees a real live person for the first time. It's a woman named M, the leader of a group of Outsiders, vagabonds and outcasts.

The story of the Raymans, a wealthy Jewish family that's falling apart. The son, Clark, is a bright and curious high schooler with a talent for manipulation. As his mother May enters treatment for a pill addiction, and he and his father Roger stop getting along, Clark thinks about running away from home. He just needs to decide where to go.