Ever since US Diplomatic Security Service Agent Hobbs and lawless outcast Shaw first faced off, they just have traded smack talk and body blows. But when cyber-genetically enhanced anarchist Brixton's ruthless actions threaten the future of humanity, they join forces to defeat him.

This sensitive and sensual film draws together several narratives spanning several decades, all of them transpiring in the same room of the same Singaporean hotel — and all of them involving sex.