Dark Minds brings together the sharp criminal minds of author and investigative journalist M. William Phelps and pre-eminent criminal profiler John Kelly to reopen unsolved homicides thought to be the work of serial killers. They are assisted in their efforts by a source known only to viewers as "13," a convict serving multiple life terms for a series of murders, who presents his theories about potential motivations behind these chilling cold cases based on his own experiences. They bring fresh eyes to unsolved serial killer investigations using the combined instincts of three unique perspectives, with hopes that it will encourage viewers to bring forward new leads.

Ben Sanderson believes he can travel to an alternate reality when he drinks alcohol, to see the love of his life, who was brutally murdered in a home invasion two years prior. As Ben starts to get a hold of his new found ability, a new threat surfaces that may kill him before he can seek the truth.

Set during the 2017 Marriage Equality plebiscite in Australia, a young trans woman comes home to find she has received her form to vote for Marriage Equality in Australia. As she goes to make her decision, she soon finds herself being terrorised by a masked assailant.