Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Chloe moves in New York's most elite circles with her lawyer husband Adam and teenage son Ethan by her side while her estranged sister Nicky tries to make ends meet and stay clean. When Adam is brutally murdered, the investigation sends shockwaves through the family and exposes long-buried secrets.

The lives and internal power struggles of a powerful and wealthy Cuban-American family running an immensely successful rum and sugar cane business in South Florida.

Over the course of one night, a young messenger in a seedy hotel delivers the fate of several tenants as he relays the messages that will ultimately change their lives forever.