Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Set before the events of ‘Soul’, 22 refuses to go to Earth, enlisting a gang of 5 new souls in attempt of rebellion. However, 22’s subversive plot leads to a surprising revelation about the meaning of life.