Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

Everyone has secrets and Olivia Pope has dedicated her life to protecting and defending the public images of the elite by keeping those secrets under wraps. Pope and her team are at the top of their game when it comes to getting the job done for their clients, but it becomes apparent that these "gladiators in suits," who specialize in fixing the lives of other people, have trouble fixing those closest at hand -- their own.

Dr. Jacob Hood is a brilliant biophysicist and special science advisor to the government who investigates scientific crises and oddities. His crusade is to protect the substance of science against those who would abuse and misuse scientific discoveries for their own gain.

Tom and his daughter Cora decide to open their guest house to short term renters, however when their first renter Elise begins to overstay her welcome, Tom is faced with the reality that he may never be able to get her to leave.

Jack and Diane are forced to leave Indiana after discovering secrets about the death of Diane's mother. When their worst fears are confirmed by the chief of police, Jack and Diane create a "Hit List" and exact revenge on everyone involved.

After reaching a dead end in an investigation of seemingly unrelated local murders, police learn all of the victims share the same peculiar birthmark.

After a nasty break-up, Faith needs a new roommate to supplement the rent and finds that something very strange is going on with the tenant who decides to move in.

Lisa learns that her stepfather, whom she hasn't seen in years, suffered a deadly fall down the stairs at the family home and that her estranged mother has been arrested for his murder. As she begins to investigate what happened, she discovers that not everything is as it seems.

After a Tarot card reader predicts a chance meeting, Shane starts to believe in fate, seeking further advice for both his love life and his business.