Western sheriff Bob Wells is preparing to marry Sally Morgan; she loves part-Indian Wanenis, whose race is an obstacle. Sally flees the wedding with hypochondriac Henry Williams, who thinks he's just giving her a ride; but she left a note saying they've eloped! Chasing them are jilted Bob, Henry's nurse Mary (who's been trying to seduce him) and others.

A religious prostitute who sees an atheist client die after blaspheming believes the next man she runs into is Jesus.