Rhode Island State Trooper Charlie Baileygates has a multiple personality disorder. One personality is crazy and aggressive, while the other is more friendly and laid back. Both of these personalities fall in love with the same woman named Irene after Charlie loses his medication.

Lindsay is stuck in the middle of her relationship with Ben and his passion for the Boston Red Sox.

In Martha's Vineyard, Mass., conjoined twins Walt and Bob Tenor make the best of their handicap by being the fastest grill cooks in town. While outgoing Walt hopes to one day become a famous actor, shy Bob prefers to stay out of the spotlight. When a fading Hollywood actress, Cher, decides to get her show "Honey and the Beaze" cancelled, she hires Walt -- and his brotherly appendage -- as her costars. But their addition surprisingly achieves the opposite.

Comments from the Farrellys, Thomas, Wessler, Damon, Kinnear, and actors Ray “Rocket” Valliere, Wen Yan Shih, Lawyer Milloy and Tom Brady. They chat about the origins of the film and its slow path to the screen, casting, the story and character development, disabilities in the film, and their use of athletes in cameos.