Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.

James "Jimmy" Chance is a clueless 24-year-old who impregnates a serial killer during a one-night-stand. Earning custody of his daughter after the mother is sentenced to death, Jimmy relies on his oddball but well-intentioned family for support in raising the child.

Female high-school athletes become unlikely teammates in the wake of unspoken trauma.