It’s 1958 Manhattan and Miriam “Midge” Maisel has everything she’s ever wanted - the perfect husband, kids, and Upper West Side apartment. But when her life suddenly takes a turn and Midge must start over, she discovers a previously unknown talent - one that will take her all the way from the comedy clubs of Greenwich Village to a spot on Johnny Carson’s couch.

Two degenerate gamblers try to pay off a debt by stealing a classic car and ransom it back to the owner.

Jimmy McNamara is an ex-writer and WWII vet turned accountant who receives a call from Vivian, his ex-fiance and nightclub singer. Vivian got a Hollywood contract and is taking Jimmy with her. All he has to do is retrieve the negatives of compromising pictures that put her bright future in danger. But Jimmy's mission might not be as simple as it seems.

A young couple wants to have a baby, but the husband has a low sperm count. They ask his idiot brother to be the sperm donor.