The New York office of the FBI brings to bear all their talents, intellect and technical expertise on major cases in order to keep their city and the country safe.

Lawyer-by-day Matt Murdock uses his heightened senses from being blinded as a young boy to fight crime at night on the streets of Hell’s Kitchen as Daredevil.

Former Syracuse, New York, police detective Carrie Wells has hyperthymesia, a rare medical condition that gives her the ability to visually remember everything. She reluctantly joins the New York City Police Department's Queens homicide unit after her former boyfriend and partner asks for help with solving a case. The move allows her to try to find out the one thing she has been unable to remember, which is what happened the day her sister was murdered.

Liza Miller, a suddenly single stay-at-home mother, tries to get back into the working world, only to find it’s nearly impossible to start at the bottom at 40-year old. When a chance encounter convinces her she looks younger than she is, Liza tries to pass herself off as 26 and lands a job as an assistant at Empirical Press. Now she just has to make sure no one finds out the secret only she and her best friend Maggie share.

John is a conflicted underachiever, and his fiance has already begun the process of trying to shape him into the husband she expects him to be. On the night before their wedding, John is given the power to freeze time, allowing him to attempt some of the seismic life changes that his disbelieving fiance wants him to make, all on the same night. Once freed from the constraints of time and others' expectations, however, John discovers that traditional marriage holds far less appeal to him than Krav Maga, baseball bats and murder.

A directionless young man finds the love of his life, and suddenly his whole world seems to make sense. But a message from his future self warns him to stay away to avoid a lifetime of pain and misery-- will the love he's found be worth it?

When a strange werewolf virus threatens to decimate first New York and then the world, a rogue general uses the disease to create an army of super-soldiers.